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The interplay between Polycomb repressive complex 2(PRC2) and non-coding RNA in health and disease

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  2. Lab of environmental epigenetics
  • Description

 

        

We developed a RADICL-ChIP strategy to understand the complexity of the RNA network genome-wide while shedding light on regulatory pathways of chromatin-associated factors. Utilizing the dynamics of Polycomb repressive complex 2 (PRC2-Ezh1) in stress response in postmitotic muscle cells as a model system.


The picture shows: C2C12 myotube intact nuclei under control and stress conditions during RADICL-ChIP protocol" because nuclear integrity during in situ steps is crucial for the aim of the experiment.

Somaiya Saferuddin ,Sabir Adroub ,and Peng Lui
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Biological and Environmental Sciences and Engineering Division

KAUST Environmental Epigenetics Program

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