support@kaust.edu.sa
+966 (12) 808-3463
logo-black
  • Home
  • Members
    • Current
    • Alumni
  • Publications
    • 2024
    • 2023
    • 2022
    • 2021
    • 2020
    • 2019
    • 2018
    • 2017
    • 2016
    • 2015
    • 2014
    • 2013
  • Videos
  • Gallery
  • Enquiries
  • 2024
breadcrumb-bg

Atlas of Circadian Metabolism Reveals System-wide Coordination and Communication Between Clocks

  1. Lab of environmental epigenetics
  2. Publications

 

 

Atlas of Circadian Metabolism Reveals System-wide Coordination and Communication Between Clocks

by Dyar KA, Lutter D, Artati A, Ceglia NJ, Liu Y, Armenta D, Jastroch M, Schneider S, de Mateo S, Cervantes M, Abbondante S, Tognini P, Orozco-Solis R, Kinouchi K, Wang C, Swerdloff R, Nadeef S, Masri S, Magistretti P, Orlando V, Borrelli E, Uhlenhaut NH, Baldi P, Adamski J, Tschöp MH, Eckel-Mahan K, Sassone-Corsi P
Year: 2018 DOI: 10.1016/j.cell.2018.08.042

Extra Information

Cell. 2018 Sep 6;174(6):1571-1585.e11. doi: 10.1016/j.cell.2018.08.042.PMID: 30193114 

Abstract

Metabolic diseases are often characterized by circadian misalignment in different tissues, yet how altered coordination and communication among tissue clocks relate to specific pathogenic mechanisms remains largely unknown. Applying an integrated systems biology approach, we performed 24-hr metabolomics profiling of eight mouse tissues simultaneously. We present a temporal and spatial atlas of circadian metabolism in the context of systemic energy balance and under chronic nutrient stress (high-fat diet [HFD]). Comparative analysis reveals how the repertoires of tissue metabolism are linked and gated to specific temporal windows and how this highly specialized communication and coherence among tissue clocks is rewired by nutrient challenge. Overall, we illustrate how dynamic metabolic relationships can be reconstructed across time and space and how integration of circadian metabolomics data from multiple tissues can improve our understanding of health and disease.

Keywords

CircadiOmics circadian rhythms clock high-fat diet metabolism metabolomics
logo-white

"KAUST shall be a beacon for peace, hope and reconciliation, and shall serve the people of the Kingdom and the world."

King Abdullah bin Abdulaziz Al Saud, 1924 – 2015

Contact Us

  • +966 12 8082714
  • amira.eltally@kaust.edu.sa
  • 4700 King Abdullah University of Science and Technology

    Thuwal 23955-6900

    Kingdom of Saudi Arabia

    Floc.23610 (Building 2, Level 3, Area 1, Sea Side

Quick links

Biological and Environmental Sciences and Engineering Division

KAUST Environmental Epigenetics Program

Facebook

© King Abdullah University of Science and Technology. All rights reserved

Privacy Policy
Terms of Use
Loading...