Characterization of piRNAs across postnatal development in mouse brain

by Yanal Ghosheh, Loqmane Seridi, Taewoo Ryu, Hazuki Takahashi, Valerio Orlando, Timothy Ravasi
Year: 2016 DOI: 10.1038/srep25039

Extra Information

Sci Rep. 2016 Apr 26;6:25039. doi: 10.1038/srep25039.PMID: 27112104


PIWI-interacting RNAs (piRNAs) are responsible for maintaining the genome stability by silencing retrotransposons in germline tissues- where piRNAs were first discovered and thought to be restricted. Recently, novel functions were reported for piRNAs in germline and somatic cells. Using deep sequencing of small RNAs and CAGE of postnatal development of mouse brain, we identified piRNAs only in adult mouse brain. These piRNAs have similar sequence length as those of MILI-bound piRNAs. In addition, we predicted novel candidate regulators and putative targets of adult brain piRNAs.