Senior research scientist in Juan Carlos Belmonte lab at San Diego Institute of Science PHD ( Altos lab )
Research Interests
L1 transposable elements analysis in progeria syndrome and cellular senescence.
Selected Publications
Francesco Della Valle1, Pradeep Reddy1, Mako Yamamoto Tsui, Javier Prieto Martinez, Alejandro Ocampo, Mirko Celii, Arianna Mangiavacchi, Leila Abassi, Juan Carlos Izpisua Belmonte & Valerio Orlando“L1 RNA knockdown averts heterochromatin loss and premature aging phenotypes”
Nadine Hosny El Said1*, Francesco Della Valle1*, Peng Liu1, Andreu Paytuví-Gallart2, Sabir Adroub1, Juliette Gimenez3, Valerio Orlando1+. PRC2-EZH1 requires Malat1 interaction for oxidative stress-dependent H3K27me3 remodeling in myotubes. Cell Death and Differentiation submitted 2021
Francesco Della Valle1, Manjula P. Thimma1, Massimiliano Caiazzo2,3,4, Salvatore Pulcrano4, Sabir A. Adroub1, Peng Liu1, Gregorio A. Lobato1 , Vania Broccoli4, Valerio Orlando1. Transdifferentiation of Mouse Embryonic Fibroblasts into Dopaminergic Neurons Reactivates LINE-1 Repetitive Elements. Stem cell Reports 2020
Beatrice Bodega, Federica Marasca, Valeria Ranzani, Alessandro Cherubini, Francesco Della Valle, Maria Victoria Neguembor, Michel Wassef, Alessio Zippo, Chiara Lanzuolo, Massimiliano Pagani, Valerio Orlando. A cytosolic Ezh1 isoform modulates a PRC2-Ezh1 epigenetic adaptive response in postmitotic cells. Nature structure and molecular biology, 2017
Corsetti V, Florenzano F, Atlante A, Bobba A, Ciotti MT, Natale F, Della Valle F, Borreca A, Manca A, Meli G, Ferraina C, Feligioni M, D'Aguanno S, Bussani R, Ammassari-Teule M, Nicolin V, Calissano P, Amadoro G. NH2-truncated human tau induces deregulated mitophagy in neurons by aberrant recruitment of Parkin and UCHL-1: implications in Alzheimer's disease. Hum Mol Genet. 2015
Borreca A, Latina V, Corsetti V, Middie S, Piccinin S, Della Valle F, Bussani R, Ammassari-Teule M, Nisticò R, Calissano P, Amador G. AD-Related N-Terminal Truncated Tau Is Sufficient to Recapitulate In Vivo the Early Perturbations of Human Neuropathology: Implications for Immunotherapy. Mol Neurobiol. 2018
Education
2005 High school diploma, scientific studies, Francesco Selmi institute with a score of 96/100
2010 Master's degree in medical and Pharmaceutical Biotechnology, University of Modena and Reggio Emilia with 110/110 cum laude.Thesis title: “Transcription factors Crx and Nrl: induction of transdifferentiation of 661w neuronal cell line into photoreceptors.”
2015 Ph.D. in Neuroscience, University of Tor Vergata. Rome, Itali -Thesis title: Line1 repetitive elements dynamic occurs in neural transdifferentiation and muscular cell differentiation
