My research project focuses on the study of the transcriptional and epigenetic mechanisms deregulated in metabolic disorders such as Type II Diabetes Mellitus (T2DM). I rely on the use of a large cohort of Induced Pluripotent Stem Cells (IPSCs) obtained from patients carrying symmetrical copy number variation associated with glucose abnormalities. We use this cellular model to derive glucose sensitive cell types in-vitro and study transcriptional signatures associated to T2DM etiopathogenesis.