• LINE-1 RNA triggers matrix formation in bone cells via a PKR-mediated inflammatory response-EMBO J (2024) https://doi.org/10.1038/s44318-024-00143-z
• Behind the scenes: How RNA orchestrates the epigenetic regulation of gene expressionBehind the scenes: How RNA orchestrates the epigenetic regulation of gene expression-Front Cell Dev Biol- 2023 Jan 25:11:1123975. doi: 10.3389/fcell.2023.1123975.
• LINE-1 RNA causes heterochromatin erosion and is a target for amelioration of senescent phenotypes in progeroid syndromesLINE-1 RNA causes heterochromatin erosion and is a target for amelioration of senescent phenotypes in progeroid syndromes- Sci Transl Med 2022 Aug 10;14(657):eabl6057. doi: 10.1126/scitranslmed.abl6057. Epub 2022 Aug 10.
• New insights on the dynamics of retrotransposons and its function in mammalian somatic cells Mangiavacchi A*, Della Valle F*, Liu P*, Orlando V Cell Mol Life Sci, 2021 * co-first authors
• The miR-223 host non-coding transcript linc-223 induces IRF4 expression in acute myeloid leukemia by acting as a competing endogenous RNA Mangiavacchi A, Sorci M, Masciarelli S, Larivera S, Legnini I, Iosue I, Bozzoni I, Fazi F, Fatica A Oncotarget. 2016 Aug 9. doi: 10.18632/oncotarget.11165
• A feedforward regulatory loop between HuR and the long noncoding RNA linc-MD1 controls early phases of myogenesis Legnini I*, Morlando* M, Mangiavacchi A, Fatica A, Bozzoni I Mol Cell. 2014 Feb 6;53(3):506-14. doi: 10.1016/j.molcel.2013.12.012. Epub 2014 Jan 16 * co-first authors
• The microRNA-26a target E2F7 sustains cell proliferation and inhibits monocytic differentiation of acute myeloid leukemia cells Salvatori B*, Iosue I*, Mangiavacchi A, Loddo G, Padula F, Chiaretti S, Peragine N, Bozzoni I, Fazi F, Fatica A Cell Death Dis. 2012 Oct 25;3:e413. doi: 10.1038/cddis.2012.151 * co-first authors
• Critical Role of c-Myc in Acute Myeloid Leukemia Involving Direct Regulation of miR-26a and Histone Methyltransferase EZH2 Salvatori B, Iosue I, Djodji Damas N, Mangiavacchi A, Chiaretti S, Messina M, Padula F, Guarini A, Bozzoni I, Fazi F, Fatica A Genes Cancer. 2011 May;2(5):585-92. doi: 10.1177/1947601911416357

• 2020-present: Research scientist, KAUST, Thuwal, Saudi Arabia

• 2015-2020: postdoctoral fellow, KAUST, Thuwal, Saudi Arabia

• Oct-Dec 2019: visiting scientist at ETH and University Hospital, Zurich

• 2015: Ph.D., Genetics and Molecular Biology, Sapienza, Rome, Italy Final dissertation: “Linc-223: a new player in myeloid differentiation” Supervisor: Dott. A. Fatica, University of Rome “Sapienza”, Roma, Italy

• 2011: M.Sc., Genetics and Molecular Biology, Sapienza, Rome, Italy, (110/110 with honours) Final dissertation: “MiR-26a: a new potential tumor-suppressor”. Supervisor: Dott. A. Fatica, University of Rome “Sapienza”, Rome, Italy

• 2009: Biology, Sapienza, Rome, Italy (110/110 with honors) Final dissertation: “Development of vectors for ectopic microRNAs expression in mammalian cells”. Supervisor: Dott. A. Fatica, University of Rome “Sapienza”, Rome, (Italy)