The discovery of the Epigenome marked the turning point for a better understanding of the complexity of gene regulation and phenotype variation.
While the largest part of available knowledge about Epigenetic mechanisms comes from studies performed in developmental contexts, very little is known about the function of the epigenome in adult tissues, how this changes in response to environment and time.
Far from being a rigid platform, the Epigenome controls the capacity of cells to be plastic to allow adaptation and performance in response to the natural changing of environmental conditions including metabolism, stress and aging with clear implications for the understanding of tissue homeostasis, cell reprogramming and associated diseases.
The focus of our laboratory in the newly established Epigenetics program at KAUST (keep.kaust.edu.sa) is the investigation of the mechanistic role of the Epigenome and nonconding Genome in somatic cells and in particular the role of Polycomb Group Proteins (PcG), noncoding RNA, chromatin RNAi components and repetitive mobile DNA elements in cell identity, adaptation to stress, aging and reprogramming. As model system we use human primary cells and mouse animal models, with particular emphasis on skeletal muscles, neuromuscular diseases and cell reprogramming.
Dr. Mangiavacchi’s work focuses on transposable element (TE) dynamics, particularly LINE-1 (L1), in bone. Her research aims to understand how L1 dynamics are impaired in osteoporosis, and to identify TE-based approaches that improve the anabolic potential of bone tissue.